… oocyte and early embryo, PADI6 is crucial for early embryonic development and female fertility
… cell lines, potentially affecting cellular cytoskeletal dynamics and cell migration. Together …

… KO mice are infertile, while males are fertile [93]. A similar … complex in the oocyte cytoplasm,
which is required for early … In non-reproductive models, the citrullination of cytoskeletal …

… mutations in the peptidylarginine deiminase type VI (PADI6) … in mammalian oocytes and
early embryos, essential for … cofilin controlled the formation of the actin cytoskeleton which …

… In our study, metaphase I (MI) oocytes from donors were … it in a sample of 100 healthy
Chinese women with normal fertility. … activation of the newly formed embryonic genome, which is …

… stage are important for normal ovarian function and fertility, and a … Peptidylarginine deiminase
6 (PADI6) is an enzyme that is … in oocytes results in dispersal of the cytoskeletal sheets in …

… Peptidylarginine deiminase (PAD) 6 is essential for oocyte cytoskeletal sheet formation
and female fertility. Mol Cell Endocrinol 2007; 273(1-2):25-31; PMID:17587491; http://dx.doi.org/…

… oocytes and early embryos based on our in-house database; 6) genes previously reported
to affect female fertility … PADI6 is a member of the peptidylarginine deiminase (PADI) family, a …

… Peptidylarginine deiminase (PAD) 6 is essential for oocyte cytoskeletal sheet formation and
female fertility… cytoskeletal sheet formation and female fertility. Mol Cell Endocrinol. 2007;273(…

… were proposed to be oocyte-specific in… oocyte-specific proteins that are essential for the
formation of cytoplasmic lattices. These proteins were PADI6 (peptidylarginine deiminase 6) and …

… Fusion of the sperm and egg at fertilization marks the critical oocyte-to-embryo transition
in mammals, which comprises several key developmental events. At the cellular level, …